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Prof. Nasreen Zafar Ehtesham

Prof. Nasreen Zafar Ehtesham

Distinguished Professor, Life Science

nasreen.ehtesham@sharda.ac.in

About

Prof. Nasreen Z Ehtesham is a pioneer researcher in the field of infection biology and has received more than 14 extramural funds (nearly Rs 36 crores) from ICMR, DST, DBT and IMPRINT. She was the Director of ICMR-National Institute of Pathology and Emeritus Professor before joining Sharda University as Distinguished Professor. She has published >100 peer reviewed articles (average citations per paper >29; H index 30; Citations 4454; i10 index 70), 10 book chapters, edited a book published by Springer-Nature and has >10 patents (Filed/awarded). An Elected Fellow of National Academy of Sciences, she is member of several regulatory committees. She is also on Editorial board of Journals published by Springer/BMC, etc 

Experience
  • 35 years
Qualification
  • Ph.D, 
     
Award & Recognition

  • Elected Fellow, Indian National Science Academy, New Delhi
  • Elected Fellow, The National Academy of Sciences,India
  • Elected Fellow, Andhra Pradesh Akademi of Sciences,India
  • ICMR Kshanika Award, ICMR, 2014
  • Outstanding Work of the Year Award, NII, New Delhi1990
  • Member of American Society of Biochemistry and Molecular Biology
  • Life Member, Nutritional Society of India, India; Society of Biological Chemists, India; Society of Cell Biology, India
  • DBT Task Force on Biotechnological approaches on food and nutritional security
  • Member of ICMR, CSIR committees
  • Editorial Boards of: Molecular and Cellular Biochemistry (Springer), Journal of Biosciences and Technology, Journal of Medical Science and Technology, International Journal of Life Science and Technology, Gut Pathogens (Bio Med Central), Etc.
     

Research

Selected Publications:

  • Quadir N, Shariq M, Sheikh JA, Singh J, Sharma N, Hasnain SE, Ehtesham NZ. Mycobacterium tuberculosis protein MoxR1 enhances virulence by inhibiting host cell death pathways and disrupting cellular bioenergetics. Virulence. 2023 Feb 14(1):2180230.
  • Selvapandiyan A, Puri N, Kumar P, Alam A, Ehtesham NZ, Griffin G, Hasnain SE. Zooming in on common immune evasion mechanisms of pathogens in phagolysosomes: potential broad-spectrum therapeutic targets against infectious diseases. FEMS Microbiol Rev. 2023 Jan 16;47(1)
  • Shariq M, Quadir N, Alam A, Zarin S, Sheikh JA, Sharma N, Samal J, Ahmad U, Kumari I, Hasnain SE, Ehtesham NZ. The exploitation of host autophagy and ubiquitin machinery by Mycobacterium tuberculosis in shaping immune responses and host defense during infection. Autophagy. 2023 Jan;19(1):3-23. 
  • Quadir N, Singh J, Alam A, Malik AA, Rahman SA, Hira S, Ehtesham NZ, Sundar D, Hasnain SE. Evolution of SARS-CoV-2: BA.4/BA.5 Variants Continues to Pose New Challenges. Viruses. 2022 Nov 23;14(12):2610.
  • Singh J, Vashishtha S, Rahman SA, Ehtesham NZ, Alam A, Kundu B, Dobrindt U. Energetics of Spike Protein Opening of SARS-CoV-1 and SARS-CoV-2 and Its Variants of Concern: Implications in Host Receptor Scanning and Transmission. Biochemistry. 2022 Oct 18;61(20):2188-2197.
  • Sheikh JA, Malik AA, Quadir N, Ehtesham NZ, Hasnain SE. Learning from COVID-19 to tackle TB pandemic: From despair to hope. Lancet Reg Health Southeast Asia. 2022 Jul;2:100015. 
  • Swargam S, Kumari I, Kumar A, Pradhan D, Alam A, Singh H, Jain A, Devi KR, Trivedi V, Sarma J, Hanif M, Narain K, Ehtesham NZ, Hasnain SE, Ahmad S. MycoVarP: Mycobacterium Variant and Drug Resistance Prediction Pipeline for Whole-Genome Sequence Data Analysis. Front Bioinform. 2022 Jun 3;1:805338.
  • Rani A, Alam A, Ahmad F, P M, Saurabh A, Zarin S, Mitra DK, Hasnain SE, Ehtesham NZ. Mycobacterium tuberculosis Methyltransferase Rv1515c Can Suppress Host Defense Mechanisms by Modulating Immune Functions Utilizing a Multipronged Mechanism. Front Mol Biosci. 2022 Jun 24;9:906387.
  • Ahmad F, Rani A, Alam A, Zarin S, Pandey S, Singh H, Hasnain SE, Ehtesham NZ. Macrophage: A Cell With Many Faces and Functions in Tuberculosis. Front Immunol. 2022 May 6;13:747799. 
  • Shariq M, Sheikh JA, Quadir N, Sharma N, Hasnain SE, Ehtesham NZ. COVID-19 and tuberculosis: the double whammy of respiratory pathogens. Eur Respir Rev. 2022 Apr 13;31(164):210264. 
  • Singh J, Rahman SA, Ehtesham NZ, Hira S, Hasnain SE. SARS-COV-2 variants of concern are emerging in India. Nature Medicine, 2021,https://doi.org/10.1038/s41591-021-01397-4 
  • Roy D, Ehtesham NZ, Hasnain SE. Is Mycobacterium tuberculosis carcinogenic to humans? The FASEB Journal 2021 DOI: 10.1096/fj.202001581RR 
  • Quadir N, Rahman SA, Ahmad J, Das AK, Arora N, Sheikh JA, Gupta NK, Kapur P, Dudeja M, Hasnain SE, Ehtesham NZ. Development and Validation of Signature Sequence-Based PCR for Improved Molecular Diagnosis of Tuberculosis. J Mol Diagn. 2021 Sep;23(9):1138-1144.
  • Ehtram A, Shariq M, Ali S, Quadir N, Sheikh JA, Ahmad F, Sharma T, Ehtesham NZ, Hasnain SE. Teleological cooption of Mycobacterium tuberculosis PE/PPE proteins as porins: Role in molecular immigration and emigration. Int J Med Microbiol. 2021 Apr;311(3):151495. 
  • Shariq M, Quadir N, Sharma N, Singh J, Sheikh JA, Khubaib M, Hasnain SE, Ehtesham NZ. Mycobacterium tuberculosis RipA Dampens TLR4-Mediated Host Protective Response Using a Multi-Pronged Approach Involving Autophagy, Apoptosis, Metabolic Repurposing, and Immune Modulation. Front Immunol. 2021 Mar 4;12:636644. 
  • Ali S, Ehtram A, Arora N, Manjunath P, Roy D, Ehtesham NZ, Hasnain SE. The M. tuberculosis Rv1523 Methyltransferase Promotes Drug Resistance Through Methylation-Mediated Cell Wall Remodeling and Modulates Macrophages Immune Responses. Front Cell Infect Microbiol. 2021 Mar 12;11:622487. 
  • Singh J, Samal J, Kumar V, Sharma J, Agrawal U, Ehtesham NZ, Sundar D, Rahman SA, Hira S, Hasnain SE. Structure-Function Analyses of New SARS-CoV-2 Variants B.1.1.7, B.1.351 and B.1.1.28.1: Clinical, Diagnostic, Therapeutic and Public Health Implications. Viruses. 2021 Mar 9;13(3):439. 
  • Shariq M, Quadir N, Sheikh JA, Singh AK, Bishai WR, Ehtesham NZ, Hasnain SE. Post translational modifications in tuberculosis: ubiquitination paradox. Autophagy. 2021 Mar;17(3):814-817. 
  • Ramos J, Yoo C, Felty Q, Gong Z, Liuzzi JP, Poppiti R, Thakur IS, Goel R, Vaid AK, Komotar RJ, Ehtesham NZ, Hasnain SE, Roy D. Sensitivity to differential NRF1 gene signatures contributes to breast cancer disparities. J Cancer Res Clin Oncol. 2020 Nov;146(11):2777-2815. 
  • Tripathi D, Kant S, Pandey S, Ehtesham NZ. Resistin in metabolism, inflammation, and disease. FEBS J. 2020 Aug;287(15):3141-3149.
  • Marais BJ, Chakaya J, Swaminathan S, Fox GJ, Ehtesham NZ, Ntoumi F, Zijenah L, Maurer M, Zumla A. Tackling long-term morbidity and mortality after successful tuberculosis treatment. Lancet Infect Dis. 2020 Jun;20(6):641-642.
  • Sheikh JA, Ehtesham NZ, Hasnain SE. Revisiting BCG to control tuberculosis: mucosal delivery and delipidation? Lancet Infect Dis. 2020 Mar;20(3):272-273.
  • Pandey V, Singh P, Singh S, Arora N, Quadir N, Singh S, Das A, Dudeja M, Kapur P, Ehtesham NZ, Elangovan R, Hasnain SE. SeeTB: A novel alternative to sputum smear microscopy to diagnose tuberculosis in high burden countries. Sci Rep. 2019 Nov 12;9(1):16371. 
  • Kumar A, Alam A, Grover S, Pandey S, Tripathi D, Kumari M, Rani M, Singh A, Akhter Y, Ehtesham NZ, Hasnain SE. Peptidyl-prolyl isomerase-B is involved in Mycobacterium tuberculosis biofilm formation and a generic target for drug repurposing-based intervention. NPJ Biofilms Microbiomes. 2019 Jan 15;5:3. 
  • Grover S, Sharma T, Singh Y, Kohli S, P M, Singh A, Semmler T, Wieler LH, Tedin K, Ehtesham NZ, Hasnain SE. The PGRS Domain of Mycobacterium tuberculosis PE_PGRS Protein Rv0297 Is Involved in Endoplasmic Reticulum Stress-Mediated Apoptosis through Toll-Like Receptor 4. mBio. 2018 Jun 19;9(3). 
  • Ahmad J, Farhana A, Pancsa R, Arora SK, Srinivasan A, Tyagi AK, Babu MM, Ehtesham NZ, Hasnain SE. Contrasting Function of Structured N-Terminal and Unstructured C-Terminal Segments of Mycobacterium tuberculosis PPE37 Protein. mBio. 2018 Jan 23;9(1). pii: e01712-17.