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Dr. Monika Jain

Dr. Monika Jain

Assistant Professor, Biotechnology

monika.jain@sharda.ac.in

About

Ph.D. in Biotechnology, CSIR NET-LS, with outstanding academic track record including Dissertation from Indian Institute of Sciences (IISc), Bangalore. Over 19 years of teaching and 8 years of research experience in various reputed universities of India like Banasthali University, Jaipur National University and Sharda University (currently working in department of Biotechnology, School of Engineering & Technology). Published over 34 research papers in peer reviewed journals, Authored two books (Environmental Biotechnology and Recombinant DNA Techniques). Completed many MOOCs from various reputed universities like MIT, USA, Purdue University, USA and Tel Aviv University, Israel. Taught subjects like Recombinant DNA Technology, Molecular Biology, Signal Transduction, Immunology, Cancer Biology, Biochemistry, Bioethics and IPR, Waste Management.

Experience
  • 19 years 3 months
Qualification
  • Ph.D. in Biotechnology, in 2020, Sharda University 
  • CSIR UGC NET Life sciences- securing rank 28 (Year 2016) in Life Sciences under Eligibility for Lectureship. 
  • PGDIPR (Post Graduation Diploma in Intellectual Property Rights) from IGNOU. 
  • M.Sc. Biotechnology, year 2005, University of Rajasthan. First position in University. 
  • B.Sc. CBZ, year 2002, University of Rajasthan
Award & Recognition

  • CSIR NET (LS)

Research

  • Mahur, P., Sharma, A., Jahan, G., Adithya, S. G., Kumar Singh, A., Muthukumaran, J., & Jain, M. (2024). Understanding genetic risks: Computational exploration of human β-Synuclein nsSNPs and their potential impact on structural alteration. Neuroscience letters, 137826. Advance online publication. https://doi.org/10.1016/j.neulet.2024.137826
  • Sharma, A., Mahur, P., Singh, A. Muthukumaran, J., & Jain, M. (2024)  Insights into the structural and functional analysis of impact of the missense mutations on α-synuclein: an in silico study. Egypt J Med Hum Genet 25, 60 https://doi.org/10.1186/s43042-024-00530-5
  • Kumar, A., Singh, P., Singh, E., Jain, M., Muthukumaran, J., & Singh, A. K. (2024). In silico strategies for identifying therapeutic candidates against Acinetobacter baumannii: spotlight on the UDP-N-acetylmuramoyl-L-alanine-D-glutamate:meso-diaminopimelate ligase (MurE). Journal of biomolecular structure & dynamics, 1–15. Advance online publication. https://doi.org/10.1080/07391102.2024.2325661
  • Jain Monika , Mohd Amir, Mohd Yousuf, Sharma Manish , Naik Sanjay , Kumar Sanjit ,  Muthukumaran Jayaraman, Ali Mohd Sajid , Al-LohedanHamad A.  Singh, Amit Kumar (2024) Exploration of the antiproliferative activity of lectin-like protein from seeds of Datura stramonium: An in vitro study,Journal of King Saud University - Science,Volume 36, Issue 6,103216,ISSN 1018-3647,https://doi.org/10.1016/j.jksus.2024.103216.
  • Abhishek Sharma, AmitKumar Singh, Jayaraman Muthukumaran & Monika Jain (2024)            Targeting MurB from Helicobacter pylori: insights from virtual screening, molecular docking and molecular dynamics simulation, Molecular Simulation, DOI: 10.1080/08927022.2024.2316818
  • Zia, M. P., Jain, M., Muthukumaran, J., & Singh, A. K. (2024). Exploration of potential hit compounds targeting 1-deoxy-d-xylulose 5-phosphate reductoisomerase (IspC) from Acinetobacter baumannii: an in silico investigation. 3 Biotech, 14(3), 72. https://doi.org/10.1007/s13205-024-03923-w
  • Bhati, S. K., Jain, M., Muthukumaran, J., & Singh, A. K. (2024). Computational identification of candidate inhibitors for Dihydrofolate reductase in Acinetobacter baumannii. Current research in structural biology, 7, 100127. https://doi.org/10.1016/j.crstbi.2024.100127
  • Rittik Bhati, Hazel Zadeng, Ekampreet Singh, Ankit Kumar, Monika Jain, J. Senthil Kumaran, Amit Kumar Singh & Jayaraman Muthukumaran (18 Dec 2023): Molecular dynamics simulations assisted investigation of phytochemicals as potential lead candidates against anti-apoptotic Bcl-B protein, Journal of Biomolecular Structure and Dynamics, DOI: 10.1080/07391102.2023.2295385 
  • Saurabh Kumar Bhati, Monika Jain, Jayaraman Muthukumaran & Amit Kumar Singh (2023) A computational perspective towards the identification of promising lead molecules against 6-hydroxy-methyl dihydropterin pyrophosphokinase (HPPK) from Acinetobacter baumannii, Journal of Biomolecular Structure and Dynamics, DOI: 10.1080/07391102.2023.2240423
  • Kumar, A., Singh, E., Jha, R.K. Jain, M, et al. Targeting multi-drug-resistant Acinetobacter baumannii: a structure-based approach to identify the promising lead candidates against glutamate racemase. J Mol Model 29, 188 (2023). https://doi.org/10.1007/s00894-023-05587-4
  • Ali, M. S., Muthukumaran, J., Jain, M., Tariq, M., Al-Lohedan, H. A., & Al-Sanea, A. S. S. (2023). Detailed Experimental and In Silico Investigation of Indomethacin Binding with Human Serum Albumin Considering Primary and Secondary Binding Sites. Molecules (Basel, Switzerland), 28(7), 2979. https://doi.org/10.3390/molecules28072979
  • Jain, M. et al. (2023). Introduction to Protein Therapeutics. In: Singh, D.B., Tripathi, T. (eds) Protein-based Therapeutics. Springer, Singapore. https://doi.org/10.1007/978-981-19-8249-1_1
  • Khan, R. J., Singh, E., Jha, R. K., Kumar, A., Bhati, S. K., Zia, M. P., Jain, M., Singh, R. P., Muthukumaran, J., & Singh, A. K. (2023). Identification and prioritization of potential therapeutic molecules against LpxA from Acinetobacter baumannii - A computational study. Current research in structural biology, 5, 100096. https://doi.org/10.1016/j.crstbi.2023.100096
  • Parveez Zia, M., Singh, E., Jain, M., Muthukumaran, J., & Singh, A. K. (2023). Structural and functional characterization of 1-deoxy-D-xylulose-5-phosphate synthase (DXS) from Acinetobacter baumannii: identification of promising lead molecules from virtual screening, molecular docking and molecular dynamics simulations. Journal of biomolecular structure & dynamics, 41(21), 11598–11611. https://doi.org/10.1080/07391102.2023.2174598
  • Sharma, A., Mahur, P., Muthukumaran, J., Singh, A. K., & Jain, M. (2023). Shedding light on structure, function and regulation of human sirtuins: a comprehensive review. 3 Biotech, 13(1), 29. https://doi.org/10.1007/s13205-022-03455-1
  • Jha, R. K., Singh, E., Khan, R. J., Kumar, A., Jain, M., Muthukumaran, J., & Singh, A. K. (2022). Droperidol as a potential inhibitor of acyl-homoserine lactone synthase from A. baumannii: insights from virtual screening, MD simulations and MM/PBSA calculations. Molecular diversity, 10.1007/s11030-022-10533-2. Advance online publication. https://doi.org/10.1007/s11030-022-10533-2
  • Singh, E., Jha, R. K., Khan, R. J., Kumar, A., Jain, M., Muthukumaran, J., & Singh, A. K. (2022). A computational essential dynamics approach to investigate structural influences of ligand binding on Papain like protease from SARS-CoV-2. Computational biology and chemistry, 99, 107721. https://doi.org/10.1016/j.compbiolchem.2022.107721
  • Mangal, P., Jha, R. K., Jain, M., Singh, A. K., & Muthukumaran, J. (2022). Identification and prioritization of promising lead molecules from Syzygium aromaticum against Sortase C from Streptococcus pyogenes: an in silico investigation. Journal of biomolecular structure & dynamics, 1–18. Advance online publication. https://doi.org/10.1080/07391102.2022.2086921
  • Jha, R. K., Jabeer Khan, R., Singh, E., Kumar, A., Jain, M., Muthukumaran, J., & Singh, A. K. (2022). An extensive computational study to identify potential inhibitors of Acyl-homoserine-lactone synthase from Acinetobacter baumannii (strain AYE). Journal of molecular graphics & modelling, 114, 108168. https://doi.org/10.1016/j.jmgm.2022.108168
  • Parthiban, A., Sachithanandam, V., Lalitha, P., Elumalai, D., Asha, R. N., Jeyakumar, T. C., Muthukumaran, J., Jain, M., Jayabal, K., Mageswaran, T., Sridhar, R., Purvaja, R., & Ramesh, R. (2022). Isolation and biological evaluation 7-hydroxy flavone from Avicennia officinalis L: insights from extensive in vitro, DFT, molecular docking and molecular dynamics simulation studies. Journal of biomolecular structure & dynamics, 1–13. Advance online publication. https://doi.org/10.1080/07391102.2022.2039771
  • Jain Monika, Amera GM, Jayaraman Muthukumaran, Singh AK; Insights into biological role of plant defense proteins: A review, Biocatalysis and Agricultural Biotechnology Journal ,Volume 40, March 2022, 102293
  • V. Sachithanandam, P. Lalitha, A. Parthiban, Jayaraman Muthukumaran, Monika Jain, Ranjita Misra, T. Mageswaran, R. Sridhar, R. Purvaja & R. Ramesh (2021) Isolation and biological evaluation of novel bioactive natural product, mucic acid analogue from Rhizophora apiculata: Insights from extensive in vitro and in silico studies with anti-apoptotic proteins J Biomol Struct Dyn. 2021 Sep 
  • Khan RJ, Jha RK, Singh E, A. Parthiban, Jain M, E Singh, Amera GM, Ramachandran, Purvaja, Ramachandran, Ramesh, Singh RP, V, Sachithanandam, Muthukumaran J, Singh AK. Identifying the natural compound Catechin from tropical mangrove plants as a potential lead candidate against 3CLpro from SARS-CoV-2: an integrated in silico approach. J Biomol Struct Dyn. 2021 Sep.
  • Mohd. Sajid Ali, Jayaraman Muthukumaran, Monika Jain, Abdullah Saad S. Al-Sanea, Hamad A. Al-Lohedan, Experimental and in silico investigation on the interaction of indomethacin with bovine serum albumin: Effect of sodium dodecyl sulfate surfactant monomers on the binding, Journal of Molecular Liquids, Volume336, 2021, 116858,ISSN 0167-7322, https://doi.org/10.1016/j.molliq.2021.116858.
  • Mohd Sajid Ali, Jayaraman Muthukumaran, Monika Jain, Hamad A. Al-Lohedan, M. Abul Farah & Osama Ibrahim Alsowilem (2021) Experimental and computational investigation on the binding of anticancer drug gemcitabine with bovine serum albumin, Journal of Biomolecular Structure and Dynamics, DOI: 10.1080/07391102.2021.1924270
  • Mohd Sajid Ali, Jayaraman Muthukumaran, Monika Jain, Teresa Santos-Silva, Hamad A. Al-Lohedan, Noura Saad Al-Shuail, Molecular interactions of cefoperazone with bovine serum albumin: Extensive experimental and computational investigations, Journal of Molecular Liquids, Volume 337,2021,116354,ISSN 0167-7322, https://doi.org/10.1016/j.molliq.2021.116354.
  • V. Sachithanandam, P. Lalitha, A. Parthiban, Jayaraman Muthukumaran, Monika Jain, Ranjita Misra, T. Mageswaran, R. Sridhar, R. Purvaja & R. Ramesh (2021) A comprehensive in silico and in vitro studies on quinizarin: a promising phytochemical derived from Rhizophora mucronata Lam, Journal of Biomolecular Structure and Dynamics, DOI: 10.1080/07391102.2021.1894983.
  • Singh E, Khan RJ, Jha RK, Amera GM, Jain M, Singh RP, Muthukumaran J, Singh AK. A comprehensive review on promising anti-viral therapeutic candidates identified against main protease from SARS-CoV-2 through various computational methods. J Genet Eng Biotechnol. 2020 Nov 3;18(1):69. doi: 10.1186/s43141-020-00085-z. PMID: 33141358; PMCID: PMC7607901.
  • Jha RK, Khan RJ, Amera GM, Singh E, Pathak A, Jain M, Muthukumaran J, Singh AK. Identification of promising molecules against MurD ligase from Acinetobacter baumannii: insights from comparative protein modelling, virtual screening, molecular dynamics simulations and MM/PBSA analysis. J Mol Model. 2020 Oct 17;26(11):304. doi: 10.1007/s00894-020-04557-4. PMID: 33068184.
  • Amera GM, Khan RJ, Pathak A, Jha RK, Jain M, Muthukumaran J, Singh AK. Structure based drug designing and discovery of promising lead molecules against UDP-N-acetylenolpyruvoylglucosamine reductase (MurB): A potential drug target in multi-drug resistant Acinetobacter baumannii. J Mol Graph Model. 2020 Nov;100:107675. doi: 10.1016/j.jmgm.2020.107675.
  • Khan RJ, Jha RK, Singh E, Jain M, Amera GM, Singh RP, Muthukumaran J, Singh AK. Identification of promising antiviral drug candidates against non-structural protein 15 (NSP15) from SARS-CoV-2: an in silico assisted drug-repurposing study. J Biomol Struct Dyn. 2020 Sep 4:1-11. doi: 10.1080/07391102.2020.1814870.
  • Sachithanandam V, Parthiban A, Lalitha P, Muthukumaran J, Jain M, Elumalai D, Jayabal K, Sridhar R, Ramachandran P, Ramachandran R. Biological evaluation of gallic acid and quercetin derived from Ceriops tagal: insights from extensive in vitro and in silico studies. J Biomol Struct Dyn. 2020 Sep 30:1-13. doi: 10.1080/07391102.2020.1828173.
  • Khan RJ, Jha RK, Amera GM, Jain M, Singh E, Pathak A, Singh RP, Muthukumaran J, Singh AK. Targeting SARS-CoV-2: a systematic drug repurposing approach to identify promising inhibitors against 3C-like proteinase and 2'-O-ribose methyltransferase. J Biomol Struct Dyn. 2020 Apr 20:1-14. doi: 10.1080/07391102.2020.1753577.
  • Jain M, Muthukumaran J, Singh AK. Comparative structural and functional analysis of STL and SLL, chitin-binding lectins from Solanum spp. J Biomol Struct Dyn. 2020 Jun 22:1-16. doi: 10.1080/07391102.2020.1781693.
  • Jain M, Muthukumaran J, Singh AK. Structural and functional characterization of chitin binding lectin from Datura stramonium: insights from phylogenetic analysis, protein structure prediction, molecular docking and molecular dynamics simulation. J Biomol Struct Dyn. 2020 Mar 11:1-19. doi: 10.1080/07391102.2020.1737234. Epub ahead of print. PMID: 32116131.

Book Chapters

  • Ekampreet Singh, Rameez Jabeer Khan, Rajat Kumar Jha, Gizachew Muluneh Amera, Monika Jain, Rashmi Prabha Singh, Jayaraman Muthukumaran, and Amit Kumar Singh. Ligand-Based Approaches for the Development of Drugs Against SARS-CoV-2; Methods in Pharmacology and Toxicology 2021/4/6.
  • Ekampreet Singh, Rameez Jabeer Khan, Rajat Kumar Jha, Gizachew Muluneh Amera, Monika Jain, Rashmi Prabha Singh, Jayaraman Muthukumaran, and Amit Kumar Singh. Computational Drug Repurposing for the Development of Drugs Against Coronaviruses; Methods in Pharmacology and Toxicology; 2021/4/6.
  • Introduction to Protein Therapeutics, Monika Jain, Ankit Kumar, Rameez Jabeer Khan, Rajat Kumar Jha, Ekampreet Singh, Jayaraman Muthukumaran*, and Amit Kumar Singh*

Membership of Societies

  1. Life time member of Indian Crystallographic Association- membership  no. LM778.
  2. Life time member of The Biotech Research Society, India - membership no. LM2643

MOOCs  Completed

  1. Biological Engineering Cellular Design Principles from Purdue University, USA
  2. Molecular Biology –Transcription and Transposition" from MIT, USA
  3. Molecular Biology- RNA Processing and Translation" From MIT, USA
  4. Viruses & How to Beat Them Cells, Immunity, Vaccines, From Tel Aviv University, Israel
  5. Molecular Biology – DNA Replication and Repair" from MIT, USA
  6. 4 Week MOOC on Covid19-novel-coronavirus- London School    of Hygiene & Tropical Medicine and UK Public Health Rapid Support Team
  7. Drug Design and Molecular Docking by Computational tools-UDEMY
  8. Bioinformatics-Learn Docking and Mol Dynamics simulation- UDEMY
  9. Bioinformatics from Scratch (Theory and Practical)-UDEMY
     

Certifications

Certifications 
1.    PGDIPR from IGNOU.
2.    Certificate in Computing from IGNOU.
3.    CSIR NET-LS

Area of Interest

  • Bioinformatics
  • Protein structural Biology
  • Infectious Diseases