Dr. Chaitenya Verma

About

Dr. Chaitenya Verma is currently working as an Assistant Professor at the Department of Biotechnology, Sharda University, Greater Noida, Uttar Pradesh, India. Dr. Verma has done his PhD at the All India Institute of Medical Sciences (AIIMS), New Delhi focusing on the field of infection immunobiology in HIV-TB co-infected patients. His research aimed to understand the immune regulation of Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome (TB-IRIS) in HIV patients. He did his postdoctoral training at the Dr. B. R. Ambedkar Center for Biomedical Research (ACBR) at Delhi University, where he studied the role of calcium channels in modulating key players of the innate immune system, such as dendritic cells (DCs) and macrophages, and their effects on regulating effector T cell responses in Staphylococcus aureus and M. tuberculosis infection. Further, he joined The Ohio State University, Columbus, Ohio, USA, where he continued his work in infection biology to target Leishmaniasis, which is highly prominent in Eastern regions India. His work at Ohio State University involved interpreting Leishmania host-pathogen interaction and evaluating immunological paradigms such as inflammatory monocytes, dendritic cells, and other immunological parameters to create a vaccine against visceral and cutaneous Leishmania. Additionally, he worked to develop new  combinations of drugs to improve existing therapeutic methods.

Experience

6 years 5 months

Post Doc: The Ohio State University, Columbus, Ohio, USA
(Oct-2019 – Nov-2023)

Research Associate: Dr B R Ambedkar Center for Biomedical Research (ACBR), Delhi University, Delhi, India
(Sept-2017 – Sept- 2019)

Research Officer: All India Institute of Medical Sciences, New Delhi, India 
(Feb-2017 – Aug-2017)

Qualification

PhD. Immunology
All India Institute of Medical Sciences, New Delhi, India
2012-2016

M.Sc. Biotechnology
IAMR collage, Ghaziabad, under Chaudhary Charan Singh University
2006-2008

B.Sc. Biotechnology (H)
IAMR collage, Ghaziabad, under Chaudhary Charan Singh University
2003-2006
 

Research

1. Gaurav Kaushik, Richa Vashishtha, Chaitanya Verma, Shipra Sharma, Vinay Kumar. “Role of genetic variation in toll-like receptors (TLRs) 2, 4, and 9 in HIV disease progression toward active TB and AIDS”. Journal of Inflammation Research. May 2024 Volume 2024:17 Pages 3283—3291.
2. Rana AK, Kumar Saraswati SS, Anang V, Singh A, Singh A, Verma C, Natarajan K. “Butyrate induces oxidative burst mediated apoptosis via Glucose-6-Phosphate Dehydrogenase (G6PDH) in macrophages during mycobacterial infection.” Microbes Infect. 2023 Nov 29:105271.
3. Karagiannis K*, Gannavaram S*, Verma C, Pacheco-Fernandez T, Bhattacharya P, Nakhasi HL, Satoskar AR. “Dual-scRNA-seq analysis reveals rare and uncommon parasitized cell populations in chronic L. donovani infection”. Cell Rep. 2023 Sep 26;42(9):113097.
4. Anang V, Singh A, Kumar Rana A, Saraswati SSK, Bandyopadhyay U, Verma C, Chadha A, Natarajan K. “Mycobacteria modulate SUMOylation to suppresses protective responses in dendritic cells”. PLoS One. 2023 Sep 29;18(9):e0283448.
5. Bijay Kumar Jha, Sanjay Varikuti, Chaitenya Verma, Rahul Shivahare, Nick Bishop, Gregory P Dos Santos, Jacquelyn McDonald, Aakash Sur, Peter J. Myler, Sergio Schenkman, Abhay A. Satoskar, Bradford S. McGwire. Sergio Schenkman, Abhay A. Satoskar, Bradford S. McGwire. “Immunization with a Trypanosoma cruzi cyclophilin 19 deletion mutant is highly protective against wildtype challenge in a mouse model of acute Chagas disease”. NPJ Vaccines. 2023 Apr 25;8(1):63.
6. Attri, Shivangi, Moien Lone, Amit Katiyar, Vikas Sharma, Vinay Kumar, Chaitenya Verma, and Suresh Kumar Gahlawat. 2023. "Genetic Analysis of HIBM Myopathy-Specific GNE V727M Hotspot Mutation Identifies a Novel COL6A3 Allied Gene Signature That Is Also Deregulated in Multiple Neuromuscular Diseases and Myopathies" Genes 14, no. 3: 567.
7. Greta Volpedo, Thalia Pacheco-Fernandez, Erin A. Holcomb, Wen-Wei Zhang, Patrick Lypaczewski, Blake Cox, Rebecca Fultz, Chelsea Mishan, Chaitenya Verma, Ryan H. Huston, Abigail R. Wharton, Ranadhir Dey, Subir Karmakar, Steve Oghumu, Shinjiro Hamano, Sreenivas Gannavaram, Hira L. Nakhasi, Greg Matlashewski & Abhay R. Satoskar. “Centrin-deficient Leishmania mexicana confers protection against New World cutaneous leishmaniasis”. npj Vaccines 7, 32 (2022).
8. Chaitenya Verma*, Sanjay Varikuti*, Erin Holcomb*, Agostinho Viana, Bijay Kumar Jha, Ritvik Maryala, Felipe Lamenza, Tracey Papenfuss, Steve Oghumu, Sreenivas Gannavaram, Hira L. Nakhasi, Abhay R Satoskar. “MicroRNA-21 deficiency promotes the early Th1 immune responses and resistance towards visceral leishmaniasis.” *Equal contribution for first authorship. J Immunol. 2021 Aug 2:ji2001099.
9. Shaheen N, Verma C, Pacheco-Fernandez T, Volpedo G, Hamid A, Zeb I, Shah SAA, Fahad S, Iqbal A, Ashraf A, Khan A, Gul M, Khan MI, Fatima H, Afzal M, Satoskar AR, Qureshi NA. “Molecular characterization and genetic diversity of cutaneous leishmaniasis from Northeastern Pakistan”. Acta Trop. 2021:105964.
10. Aayushi Singh, Vandana Anang, Chaitenya Verma, Shakuntala Surender Kumar Saraswati, Ankush Kumar Rana, Upasana Bandyopadhyay, Attinder Chadha, Krishnamurthy Natarajan. “Bcl2 negatively regulates Protective Immune Responses During Mycobacterial Infection”. Biomol Concepts. 2021 Jul 25;12(1):94-109.
11. Shivangi Attri, Vikas Sharma, Amit Kumar, Chaitenya Verma and Suresh Kumar Gahlawat. “Dissecting role of founder mutation p.V727M in GNE in Indian HIBM cohort”. Open Medicine; https://doi.org/10.1515/med- 2021-0391.
12. Sanjay Varikuti, Chaitenya Verma, Gayathri Natarajan, Steve Oghumu, Abhay R Satoskar. “MiR155 deficiency inhibits Th2 response and accelerates resolution of cutaneous L. major infection”. Am J Pathol. 2021; 191(5):809-816.
13. Verma C, Ankush KR, Anang V, Tiwari BK, Singh A, Surender Kumar Saraswati S, Shariff M, Natarajan K. “Calcium Dynamics Regulate Protective Responses and Growth of Staphylococcus aureus in Macrophages”. Biomol Concepts. 2020 Dec 31;11(1):230-239.
14. Sarat Kumar Kottarath, Madhusudan Bhat, Chaitenya Verma, Sukrit Bhattacharya, Ankur Kaul, Uma Kumar, Amit Kumar Dinda. “Folate receptor-β targeted cholesterol-chitosan nanocarrier for treatment of rheumatoid arthritis: An animal study.” Journal of Drug Delivery Science and Technology, Vol.60, 2020; 101946.
15. Aayushi Singh, Vandana Anang, Ankush Kumar Rana, Chaitenya Verma, Shakuntala Surender Kumar Saraswati, Priyanka Kumari, Aarti Singh, Krishnamurthy Natarajan. “Deciphering the Role of Calcium Homeostasis in T cells Functions During Mycobacterial Infection”. Cellular Immunology, Vol.357, 2020; 104198.
16. Varikuti S, Singh B, Volpedo G, Ahirwar DK, Jha BK, Saljoughian N, Viana AG, Verma C, Hamza O, Halsey G, Holcomb EA, Maryala RJ, Oghumu S, Ganju RK, Satoskar AR. “Ibrutinib treatment inhibits breast cancer progression and metastasis by inducing conversion of myeloid-derived suppressor cells to dendritic cells”. Br J Cancer. 2020 Feb 6. 32025027.
17. Chaitenya Verma, Surendra K. Sharma, Krishnamurthi Natarajan, Vishnu Sreenivas, Vishwanath Upadhyay, Sanjeev Sinha, Sanjay Ranjan, Narinder K. Mehra, Gurvinder Kaur, Smriti Hari. “Immunological alterations in tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) in HIV- infected patients”. IJEB, 2019 Vol.57 (11) 786-795. Correspondence
18. Saha PK, Sharma PK, Singh BK, Verma C. “Role of CXCR3+CCR5+ Th1 cells in pulmonary tuberculosis patients: At pathogenic site”. Biomed Biotechnol Res J 2019; 3:80-6.
19. Prit Benny Malgulwar, Vikas Sharma, Ashutosh Tomar, Chaitenya Verma, Aruna Nambirajan, Manmohan Singh, Vaishali Suri, Chitra Sarkar, Mehar Chand Sharma. “Transcriptional co-express regulatory network for Snail and Slug identifies IL1R1, a inflammatory cytokine receptor to be preferentially expressed in ST- EPN-RELA and PF-EPN-A molecular subgroups of intracranial ependymomas”. Oncotarget. 2018; 9:35480- 35492.
20. Ryan H. Huston, Blake Cox, Yulian Mercado, Chaitenya Verma, Abby Wharton, Thalia Pacheco- Fernandez, Greta Volpedo, Max Gessner, Junqi Lu, Jennifer Y. Zhang, Andrew Sachan, Roger Narayan, Abhay R Satoskar. “Microneedle-based injection of Fungizone/Amphotericin- B is an effective treatment for American cutaneous leishmaniasis in mice”. *Under communication.
21. Aarti Singh, Akshita Singh, Shakuntala Surender Kumar Saraswati, Ankush Kumar Rana, Aayushi Singh, Chaitenya Verma, Vishal Sinha, Kanika Kalra, Krishnamurthy Natarajan. “Suppressive effects of Toll-Like Receptor 2, Toll-Like Receptor 4, and Toll-Like Receptor 7 on protective responses to mycobacteria from epithelial cells” *Under communication: Microbes and Infection

Review articles:

• Srivastava, S., Tyagi, A., Pawar, V. A., Khan, N. H., Arora, K., Verma, C., & Kumar, V. (2024). “Revolutionizing Immunotherapy: Unveiling New Horizons, Confronting Challenges, and Navigating Therapeutic Frontiers in CAR-T Cell-Based Gene Therapies”. ImmunoTargets and Therapy, 13, 413–433. *Equal correspondence
• Verma C*, Pawar VA*, Tyagi A*, Sharma KP, Ansari S, Mani I, Srivastva SK, Shukla PK, Kumar A, Kumar V. “Unlocking therapeutic potential: integration of drug repurposing and immunotherapy for various disease targeting”. Am J Transl Res. 2023 Aug 15;15(8):4984-5006. *Equal contribution for first authorship.
• Verma C, Pawar VA, Srivastava S, et al. “Cancer Vaccines in the Immunotherapy Era: Promise and Potential”. Vaccines (Basel). 2023;11(12):1783.
• Mittal M, Kumari A, Paul B, Varshney A, Bhavya, Saini A, Verma C, Mani I. “Challenges and Opportunities of Gene Therapy in Cancer”. OBM Genetics 2024; 8(1): 219; doi:10.21926/obm.genet.2401219.
• Chaitenya Verma*, Thalia Pacheco-Fernandez*, Greta Volpedo*, Abhay R Satoskar. “Understanding the immune responses involved in mediating protection or immunopathology during leishmaniasis.” Biochem Soc Trans. 2021; 49(1):297-311. *Equal contribution for first authorship.
• Chaitenya Verma, Bharati Swami, Vishwanath Upadhyay, Aayushi Singh, Vandana Anang, Shakuntala Surender Kumar Saraswati, Ankush Kumar Rana. “Tuberculosis and tuberculosis-associated immune reconstitution inflammatory syndrome in HIV: immunological review of manifestation and immunopathogenesis”. HIV & AIDS Rev 2020; 19, 2: 67-73.
• Thalia Pacheco-Fernandez*, Hannah Markle*, Chaitenya Verma, Ryan Huston, Sreenivas Gannavaram, Hira L. Nakhasi, Abhay R. Satoskar. “Field-deployable treatments for leishmaniasis: intrinsic challenges, recent developments and next step”. *Equal first authorship, Research and Reports in Tropical Medicine; 2023:14 61–85.
• Olivia Battistoni, Ryan Huston, Chaitenya Verma, Thalia Pacheco Fernandez, Alison Campbell, Sara Abul- Kahoudoud, Abhay Satoskar. “Understanding of Sex-biases Human Kinetoplastid Infections: Leishmania Leishmaniasis & Trypanosomiasis disease”. *Under Communication.
• Ryan H. Huston, Hannah Markle, Thalia Pacheco-Fernandez, Blake Cox, Chaitenya Verma, Sreenivas Gannavaram, Hira L. Nakhasi, Abhay R. Satoskar. “Refuges for Leishmania – Evidence of Symptomatic and Asymptomatic Leishmania Infection in Unconventional Body Sites”. *Under Communication.

Book chapters:

• Verma C, Jain K, Saini A, Mani I, Singh V. “Exploring the potential of drug repurposing for treating depression”. Prog Mol Biol Transl Sci. 2024;207:79-105.
• Chaitenya Verma, Ryan H. Huston, Abigail R. Wharton, Rebecca Fultz, Samer Zidan, Greta Volpedo, Abhay R. Satoskar. “Critical Roles of Micro-RNAs in the Pathogenesis and Immunoregulation of Leishmania Infection”. In: Selvapandiyan, A., Singh, R., Puri, N., Ganguly, N.K. (eds) Challenges and Solutions Against Visceral Leishmaniasis. Springer Nature, Singapore.
• Mathuria, A., Jain, K., Saini, A., Verma, C., Mani, I. (2024). “Metatranscriptomics, Metaproteomics, and Metabolomics Approaches for Microbiome Characterization”. In: Mani, I., Singh, V. (eds) Multi-Omics Analysis of the Human Microbiome. Springer, Singapore. https://doi.org/10.1007/978-981-97-1844-3_6
• Saini, A., Mani, I., Rawal, M.K., Verma, C., Singh, V., Mishra, S.K. (2023). “An Introduction to Microbial Genomic Islands for Evolutionary Adaptation and Pathogenicity.” In: Mani, I., Singh, V., Alzahrani, K.J., Chu, DT. (eds) Microbial Genomic Islands in Adaptation and Pathogenicity. Springer, Singapore. https://doi.org/10.1007/978-981-19-9342-8_1
• Sakshi, Ragini, Ashok Saini, Chaitenya Verma, Indra Mani. “Epigenetics in renal diseases, Progress in Molecular Biology and Translational Science”. Academic Press,2023, ISSN 1877-1173, https://doi.org/10.1016/bs.pmbts.2023.02.013.
• Anang V, Singh A, Kottarath SK, Verma C. “Receptors of immune cells mediates recognition for tumors”. Prog Mol Biol Transl Sci. 2023; 194:219-267. Epub 2022 Nov 2. Correspondence
• Singh A, Anang V, Kumari K, Kottarath SK, Verma C. “Role of lymphocytes, macrophages and immune receptors in suppression of tumor immunity”. Prog Mol Biol Transl Sci. 2023; 194:269-310. Epub 2022 Nov 17. Correspondence
• Shaheen, N., Verma, C., Qureshi, N. A. “Plant-Based Alternative Treatment for Leishmaniasis: A Neglected Tropical Disease”. London: IntechOpen; 2022 . doi: 10.5772/intechopen.101958.
   

Area of Interest

• Human Immunology 
• Host pathogen interaction
• Clinical Immunology
• Flow-cytometry
• Infectious Disease Immunology 
• Cell Biology | Immunotherapy