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Dr ANWAR ALAM

Dr ANWAR ALAM

Assistant Professor, Life Science

anwar.alam@sharda.ac.in

About

Dr Anwar Alam was awarded his Ph.D degree from Jawaharlal Nehru University, New Delhi. He has more than 10 years of experience in research post-PhD and 4 years in academic teaching. His area of specialization is Nanoparticle based drug-targeting and Infectious biology. He earlier worked as project Scientist at the ICMR-National Institute of Pathology (ICMR-NIP) and Department of Biochemical Engineering & Biotechnology, IIT-Delhi. He was a member of ICMR-NIP core team for COVID-19 management, where he played key role in establishing central depot for disbursement for COVID-19 kits across India, established labs for sample testing and kit validation. For his exemplary work during COVID-19 pandemic, he was awarded the “COVID warrior” by the ICMR-NIP. He has been the team member in projects funded by DBT, DST and ICMR; and successfully completed four projects. The main thrust of research in these projects were to explore the epidemiology and multi-drug resistance of Tuberculosis using Next-generation Sequencing, develop new chemical entities including drug-repurposing and host directed therapies for Tuberculosis (TB). He is part of team that has developed a first-in class drug to target latent TB bacilli. He is currently leading a team of researchers including post-doc Scientists in three extramural projects on Development of Biomarker for screening TB, AI ML based prediction of multi-drug resistance and testing of a low-cost field deployable tool for TB detection. He has filed several more than 7 patents that includes medicaments for treatment of infections caused by biofilm forming pathogens and recombinant multi-epitope vaccines. 

Experience
  • 10 years of Research experience and 4 years of academic experience
Qualification
  • PhD
Award & Recognition

Total Rewards -  10

  • Awarded COVID-Warrior from ICMR-National Institute of Pathology for services during COVID-19 from March 2020 to March 2021
  • Awarded Department of Biotechnology Research Associateship 2016-2018.
  • Young Scientist Award by Microwave Applications Society of India (MASI) 2011.
  • Awarded Indian Council of Medical Research (ICMR) Senior Research Fellowship 2010 and Junior Research Fellowship 2008.
  • Life Member-Indian Immunology Society, Indian Society of Cell Biologist, Indian Association of Cancer Research
  • Editorial Board- Frontiers Journal
     

Research

Total Research -  Research Publications: 26; Patents: 7; Book Chapters: 5

  • Zarin S, Shariq M, Rastogi N, Ahuja Y, Manjunath P, Alam A, Hasnain SE, Ehtesham NZ. Rv2231c, a unique histidinol phosphate aminotransferase from Mycobacterium tuberculosis, supports virulence by inhibiting host-directed defense. Cell Mol Life Sci. 2024;81(1):203. 
  • Arora SK, Alam A, Naqvi N, Ahmad J, Sheikh JA, Rahman SA, Hasnain SE, Ehtesham NZ. Immunodominant Mycobacterium tuberculosis Protein Rv1507A Elicits Th1 Response and Modulates Host Macrophage Effector Functions. Front Immunol. 2020 Jul 21;11:1199.
  • Kumar A, Alam A*, Grover S, Pandey S, Tripathi D, Kumari M, Rani M, Singh A, Akhter Y, Ehtesham NZ, Hasnain SE. Peptidyl-prolyl isomerase-B is involved in Mycobacterium tuberculosis biofilm formation and a generic target for drug repurposing-based intervention. NPJ Biofilms Microbiomes. 2019 Jan 15;5(1):3. (*Equal First Author)
  • Kumar A, Alam A*, Rani M, Ehtesham NZ, Hasnain SE. Biofilms: Survival and defense strategy for pathogens. Int J Med Microbiol. 2017;307(8):481-489. (*Equal First Author)
  • Alam A, Sachar S, Puri N, Saxena RK. Interactions of polydispersed single-walled carbon nanotubes with T cells resulting in downregulation of allogeneic CTL responses in vitro and in vivo. Nanotoxicology. 2013;7(8):1351-60.
     

Certifications

Total Certification –  3

  • Certification in handling Biosafety Level 3 pathogen 
  • Multicolour Flow Cytometry (BD Biosciences)
  • Confocal Microscopy (Nikon)
     

Area of Interest

  • Infectious Disease Biology, 
  • Drug Development
  • Medical Devices anti-biofilm