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Dr. Annette Angel

Dr. Annette Angel

Associate Professor, Life Science

annette.angel@sharda.ac.in

About

Dr. Annette Angel has done her Ph.D. from Desert Medicine Research Centre (present NIIRNCD), Indian Council of Medical Research, Jodhpur, Rajasthan in the year 2012. Her doctoral work pertained to the Studies of macromolecular factors to detect dengue transmission or blocking proteins in Aedes mosquitoes wherein she reported two mosquito proteins i.e. Myosin heavy chain, non-muscle or smooth muscle of 224.1 kDa and myosin heavy chain, muscle of 224.3 kDa. Of these two proteins, non-muscle proteins had a larger structure than muscle protein which had comparatively a smaller structure. The former protein was observed to be associated with virus transmission blocking whereas muscle protein with smaller structure observed to be with virus presence. Her Masters was in the field of Zoology. She is an expert in field as well as laboratory work on Dengue and H1N1 viruses. Dr Angel has also published number of genomic sequences of Dengue and H1N1 virus sequences and obtained accession numbers in the NCBI database, USA. Dr. Annette Angel has participated as a Tutor in number of training programs on molecular diagnosis of Dengue and H1N1 viruses. Dr. Angel, has also participated in establishing molecular diagnostic laboratory of H1N1 viruses in DMRC. She has been trained at the National Institute of Virology (NIV), Pune and National Institute of Cancer Prevention and Research (NICPR), Noida. She was awarded the prestigious ICMRs Post Doctoral Research Fellowship in the year 2014.

Later she joined National Centre for Disease Control, Delhi, Ministry of H & FW as Assistant Director in the Centre for Arboviral and Zoonotic Diseases wherein she was actively involved in Research, Training, Administrative and Academic responsibilities. Besides working on Dengue and H1N1 viruses, she has also worked in areas of infectious diseases like Toxoplasmasmosis, Chikungunya, Japanese Encephalitis, Leptospirosis, Rickettsia, Leishmaniasis, Leptospirosis, Brucellosis etc. She has number of publications to her credit and has authored in number of book chapters. Dr. Annette is a reviewer in journals of National and International level. 

After joining Sharda University in the year 2020, besides teaching, she is also involved in active research guiding many students in their Internships, Dissertation and Doctoral research works. She is a member of the Centre of Excellence in Virology & Immunology.

Experience
  • 15 Years
Qualification
  • Ph.D.
  • M.Sc.
Award & Recognition

  • ICMRs Post Doctoral Fellowship Award (2014)
  • Awarded A+ grade on completion of OFDP-47:SU-GAD-TLC required for promotion under CAS of UGC and AICTE (2021).
  • Awarded A grade on completion of OFDP-85:SU-GAD-TLC required for promotion under CAS of UGC and AICTE (2022).
  • Reviewer-Transactions of Royal Society of Tropical Medicine and Hygiene Journal, UK 
  • Reviewer-Virus Disease Journal, India

Memberships & Recognitions

  • Royal Society of Tropical Medicine and Hygiene (Member)

Research

  1. Hasan MR, Sharma P, Mehta Y, Angel A, Angel B, Joshi V, Narang J. 2024. QR-code enabled additive manufactured multiplex-immunosensor to detect DENV serotypes in dengue patient validate with indirect fluorescence antibody test (IFAT). Biosensors and Bioelectronics, 263,116561.
  2. Barthwal S, Angel B, Angel A, Joshi V, Praveen U, Bhardwaj UD, et al. 2024. Evaluating the levels of C-reactive protein (CRP) among post vaccinated subjects of COVID-19 vaccine: A cohort study. Multidisciplinary Science Journal. 6. 10.31893/multiscience.2024240. DOI:10.31893/multiscience.2024240
  3. Peer NM, Joshi V, Angel A, Angel B, Chauhan VS, Shareef BM, et al. 2024. Characterization of Circulating HCV genotypes: A cohort study in Uttar Pradesh, India. Journal of Pure and Applied Microbiology.  https://doi.org/10.22207/JPAM.18.2.21
  4. Khaneja P, Angel A, Joshi V, Angel B, Shareef BM, Mohan S, et al. 2024. In-Vitro studies of Relative Intracellular Alterations caused by Three Variants of Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2). Journal of Cellular Biotechnology. DOI: 10.3233/JCB-240139.
  5. Shareef BM, Joshi V, Angel B, Angel A, Sharma B, Singh N, et al. 2024. Role of Furin activation sites as receptors for infiltration of Severe Acute Respiratory Syndrome Coronavirus-2 into human cells. Journal of Health Science and Medical Research, , p. e20241051, 2024. ISSN 2630-0559. Available at: <https://www.jhsmr.org/index.php/jhsmr/article/view/1051
  6. Sharma B, Shareef BM, Angel B, Angel A, Joshi V, Khan AS, et al. 2023. Repurposed drug molecule targeting NSP12 protein of SARS-CoV-2: An
    In-silico study. AIMS Molecular Science; 2023; 10 (4): 322-342.
  7. Shahid M, Jain P, De A, Angel B, Angel A, Mallick S, Joshi V. 2023. Synthesis, DFT study, molecular docking and larvicidal activity of Chitin inhibitor alanine derived compounds. Polyhedron. 245: 116629.
  8. Joshi V, Shareef BM, Angel B, Angel A, Joshi R, Khan AS, et al. 2023. Molecular Basis of Host-Virus Interactions to Explain Relative Transmission and Severity Caused by Omicron and Delta variants of SARS-CoV-2. Journal of Pure and Applied Microbiology17(3):1612-1619. doi: 10.22207/JPAM.17.3.22
  9. Vyas P, Jaiswal S, Joshi V, Angel B, Angel A, Manzoor U, Joshi R. 2023. Analysis of Genetic Diversity among populations of an endangered medicinal plant Commiphora wightii (Arn.) Bhandari (Guggul) using Molecular Markers. Journal of Plant Science Research, 39 (2) 141–152.
  10. Barthwal S, Angel B, Angel A, Joshi V, Shareef BM, Peer NM, et al. 2023. Neutralizing possibilities of whole virion and mRNA vaccine triggered antibodies of Wuhan strain of SARS-CoV-2 with receptor binding domains of spike proteins of Delta and Omicron strains. Asian Pacific Journal of Tropical Medicine. 16(2): 92-94.
  11. Khan AS, Angel A, Angel B, Joshi V, Shareef BM, Khaneja P, et al. 2022. Study of surface potential and hydrophobicity of amino acids in mutated spike proteins of variants of SARS-CoV-2 and its impact on attachment and internalization of virus with human host cells. Advance Studies in Biology. 14(1):111-127.
  12. Angel A, Angel B, Joshi V, Jindal M, Rastogi P, Peer NM, et al. 2022. Correlation between hematological parameters, blood urea level and mortality of Covid-19 patients. International Journal of Health and Allied Sciences. 11:70-74
  13. Angel B, Angel A, Joshi V, Jindal M, Rastogi P, Peer N, et al. 2021. Significance of addressal of clinical investigations of Kidney functions in recovery/mortality of COVID-19 patients: A preliminary study. Biosciences Biotechnology Research Communications. 14 (4): 1985-1991
  14. Joshi AP, Angel A, Angel B, Baharia RK, Rathore S, Sharma N, Yadav K, Thanvi S, Thanvi I, Joshi V. 2018. In-silico designing and testing of primers for Sanger Genome Sequencing of Dengue virus Types of Asian Origin. Journal of Genomics, 6:34-40. doi: 10.7150/jgen.22460
  15. Thanvi I, Angel A, Angel B, Joshi V, Bohra N, Chouhan R. 2017. Protein profiling of Nasopharyngeal cells of patients of Pandemic Influenza A (H1N1) 2009 virus treated with Oseltamivir Oxalate. International Journal of Basic & Applied Medical Sciences, 7(2): 11-20. ISSN no. 2277-2103
  16. Angel A, Angel B, Yadav K, Sharma N, Joshi V, Thanvi I, Thanvi S. 2017. Age of initial cohort of Dengue patients could explain the origin of disease outbreak in a setting: A case control study of Rajasthan, India. Virus Diseases, 28 (2): 205-208.  ISSN no. 2347-3584
  17. Angel A, Angel B, Joshi AP, Baharia PK, Rathore S, Joshi V. 2016. First study of complete genome of Dengue -3 virus from Rajasthan, India: genomic characterization, amino acid variations and phylogenetic analysis. Virology Reports, 6, 32-40.
  18. Angel A, Angel B, Joshi V. 2016. Rare occurrence of natural transovarial transmission of dengue virus and elimination of infected foci as a possible intervention method. Acta Tropica, 155, 1-5.
  19. Angel B, Angel A, Joshi V. 2015. Multiple dengue viruses harboured by individual mosquitoes. Acta Tropica, 150, 107-110.
  20. Angel A, Angel B, Bohra N, Joshi V. 2014. Structural study of mosquito ovarian proteins participating in Transovarial transmission of dengue viruses. International Journal of Current Microbiology and Applied Sciences, 3 (4), 565-572.
  21. Angel A, Angel B, Joshi V, Kucheria K.  2014. Sequential emergence of serological responses of human hosts in a progressive outbreak of Dengue and Dengue Hemorrhagic Fever in Rajasthan, India. Indian Journal of Applied Research,4 (5), 24-26.
  22. Joshi V, Angel A, Angel B, Kucheria K. 2013. Egg laying sites of Aedes aegypti and their elimination as the crucial etiological intervention to prevent dengue transmission in Western Rajasthan, India.  International Journal of Scientific Research,2 (12), 468-469.
  23. Joshi V, Angel B, Purohit A, Singhi M, Angel A, Bohra N. 2012. Studies on dengue outbreak in an arid town Jodhpur, Rajasthan. Journal of Communicable diseases, 44(2), 109-113.
  24. Joshi V, Angel B, Chauhan R, Bohra N, Angel A, Singhi M, Mathur A, Solanki A. 2012. Immunity in Dengue Hemorrhagic Fever patients could be sensitized by Fresh blood transfusion. Indian Journal of Medical Case Reports, 1(1), 13-14.
  25. Joshi V, Angel B, Purohit A, Singh H, Bohra N, Angel A, Chouhan R, Singhi M, Mathur A. 2012. Cases of pandemic influenza A (H1N1) 2009 in Western Rajasthan, India. Indian Journal of Medical Research, 135 (3), 437-438.

 

Patents granted/published/applied

  1. Jain P, Shahid M, Angel B, De A, Angel A, Joshi V. 2023. Organo-Copper Complex and a Larvicidal Composition comprising the same. (Patent no. 202311010155, published).
  2. Angel B, Angel A, Joshi V, Mehta I, Bhardwaj V, Shareef BM, Joshi R, Khaneja P. 2023. A High Efficacy Larvicidal Formulation from Calotropis procera. (Patent number. 202311059367, Published on September 2023)
  3. Joshi V, Angel A, Angel B, Joshi R, Shareef BM. 2024. Vaccine Targeting Conserved Region of Coronavirus (Provisional Indian Patent Application no 202411030338, filed on April 15, 2024).
  4. Shareef BM, Joshi V, Khaneja P, Angel A, Angel B, Joshi R. 2024. An Adenosine analogue based compound against Severe Acute Respiratory Syndrome-Coronavirus-2 (Provisional Patent no.  202411032512, filed on April 24, 2024).

Certifications

  • Animal Cell Culture and Virus Isolation Techniques from National Institute of Virology, Pune.
  • Basic Molecular Biology techniques relevant to Cancer Research from National Institute of Cancer Prevention & Research (NICPR, formerly ICPO), Noida
  • Molecular Biology, Genomics, Proteomics & Bioinformatics of Dengue  & H1N1 viruses from Desert Medicine Research Centre, I.C.M.R., Jodhpur
  • Training in Bioinformatics from DMRC, Jodhpur
  • Implementation Research(IR) (Online) with a focus on Infectious Diseases of Poverty (IDP),TDR,W.H.O.
  • Open WHO course (Online) on “Antimicrobial Stewardship: A competency-based approach” by W.H.O.
  • Open WHO course (Online) on “Pandemic Influenza Vaccines: National Deployment and Vaccination Plans” by W.H.O.

Area of Interest

  • Respiratory viral diseases
  • Hepatitis & Hepatocellular Carcinoma
  • Breast Cancer
  • Auto-immune diseases
  • Swine Flu (pdmH1N1)
  • Dengue