Dr. Bennet Angel

About

Dr. Bennet Angel, M.Sc, Ph.D has specialized herself in the field of Molecular biology & Virology for the past 19 years. She was awarded Gold Medal for securing first class first in the Master program at  University level. She did her doctoral degree in the year 2008 from one of the pioneer ICMR institutes, Desert Medicine Research Centre (present NIIRNCD), Jodhpur, Rajasthan. She has done significant work in the field of Dengue and Respiratory viruses and has many papers of National and International repute. During her doctoral and post-doctoral research work, she reported the first study on protein basis of Transovarial transmission of dengue virus from India. She has also worked on understanding the mechanism of Dengue Hemorrhagic fever which led to the development of a new concept that multiple dengue virus types could cause DHF during primary infection of dengue. Dr Angel has also published number of genomic sequences of Dengue and H1N1 virus sequences and obtained accession numbers in the NCBI database, USA. She is also reviewer in International journals and reviewer of extramural projects of various National & International funding agency.  She was awarded the “Research Associate” fellowship of ICMR in the year 2010. Dr. Bennet Angel has participated as a Tutor in number of training programmes on molecular diagnosis of Dengue and H1N1 viruses. She has also played a key role in establishing molecular diagnostic laboratory of H1N1 viruses in D.M.R.C (ICMR), Rajasthan. She has been the main young scientist in implementing diagnostic services of Dengue and H1N1 viruses as rendered to State Health Department.

She has also worked as Senior scientist-II in Amity University, Noida wherein she was involved in various academic, research and administrative activities.  She has a good command over the subjects she has taught which includes Elementary science (Graduate level) and specialized subjects of Post graduate level like Virology, Immunology, Genomics, Microbiology, Molecular Biology, Proteomics etc. She has even taught PhD scholars during their PhD course work in the fields of Virology & Immunology. After joining Sharda University in the year 2020, besides teaching, she is also involved in active research guiding many students in their Internships, Dissertation and Doctoral research works. She is a member of the Centre of Excellence in Virology & Immunology.

Experience

• 19 Years

Qualification

• Ph.D.
• M.Sc.

Award & Recognition

• Awarded Gold Medal for securing University “First class first” position in M. Sc. Examination (2004).
• Award of “State Level Eligibility Test” (SLET) for Lectureship accredited by University Grants Commission, New Delhi (2005)
• Awarded “Research Associateship” of ICMR (2010).
• Awarded "Elite" category certification for scoring 72% in the ICMR's (National Institute of Epidemiology) online 8 weeks course on "Fundamental in Health Research" (2018_.
• Awarded by TDR, WHO (83%) for successfully completing online course on "Implementation Research (IR) with a focus on Infectious Diseases of Poverty (IDP)" TDR-WHO/UNU-IIGH/Monash University (2018)
• Awarded A+ grade on completion of OFDP-47:SU-GAD-TLC required for promotion under CAS of UGC and AICTE (2021).
• Awarded A+ grade on completion of OFDP-85:SU-GAD-TLC required for promotion under CAS of UGC and AICTE (2022).
• Reviewer-Transactions of Royal Society of Tropical Medicine and Hygiene Journal, UK 
• Reviewer-Virus Disease Journal, India
• Reviewer-Parasites & Vectors Journal, USA
• Project evaluator -DST-SERB extramural projects
• Project evaluator-NIHR (National Institute for Health and Care Research, UK)

Memberships & Recognitions

• Royal Society of Tropical Medicine and Hygiene (Member)

Research

1. Hasan MR, Sharma P, Mehta Y, Angel A, Angel B, Joshi V, Narang J. 2024. QR-code enabled additive manufactured multiplex-immunosensor to detect DENV serotypes in dengue patient validate with indirect fluorescence antibody test (IFAT). Biosensors and Bioelectronics, 263, 116561
2. Barthwal S, Angel B, Angel A, Joshi V, Praveen U, Bhardwaj UD, et al. 2024. Evaluating the levels of C-reactive protein (CRP) among post vaccinated subjects of COVID-19 vaccine: A cohort study. Multidisciplinary Science Journal. 6. 10.31893/multiscience.2024240. DOI:10.31893/multiscience.2024240
3. Peer NM, Joshi V, Angel A, Angel B, Chauhan VS, Shareef BM, et al. 2024. Characterization of Circulating HCV genotypes: A cohort study in Uttar Pradesh, India. Journal of Pure and Applied Microbiology.  https://doi.org/10.22207/JPAM.18.2.21
4. Khaneja P, Angel A, Joshi V, Angel B, Shareef BM, Mohan S, et al. 2024. In-Vitro studies of Relative Intracellular Alterations caused by Three Variants of Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2). Journal of Cellular Biotechnology. DOI: 10.3233/JCB-240139.
5. Shareef BM, Joshi V, Angel B, Angel A, Sharma B, Singh N, et al. 2024. Role of Furin activation sites as receptors for infiltration of Severe Acute Respiratory Syndrome Coronavirus-2 into human cells. Journal of Health Science and Medical Research, , p. e20241051, 2024. ISSN 2630-0559. Available at: <https://www.jhsmr.org/index.php/jhsmr/article/view/1051
6. Sharma B, Shareef BM, Angel B, Angel A, Joshi V, Khan AS, et al. 2023. Repurposed drug molecule targeting NSP12 protein of SARS-CoV-2: An
   In-silico study. AIMS Molecular Science; 2023; 10 (4): 322-342.
7. Shahid M, Jain P, De A, Angel B, Angel A, Mallick S, Joshi V. 2023. Synthesis, DFT study, molecular docking and larvicidal activity of Chitin inhibitor alanine derived compounds. Polyhedron. 245: 116629.
8. Joshi V, Shareef BM, Angel B, Angel A, Joshi R, Khan AS, et al. 2023. Molecular Basis of Host-Virus Interactions to Explain Relative Transmission and Severity Caused by Omicron and Delta variants of SARS-CoV-2. Journal of Pure and Applied Microbiology, 17(3):1612-1619. doi: 10.22207/JPAM.17.3.22
9. Vyas P, Jaiswal S, Joshi V, Angel B, Angel A, Manzoor U, Joshi R. 2023. Analysis of Genetic Diversity among populations of an endangered medicinal plant Commiphora wightii (Arn.) Bhandari (Guggul) using Molecular Markers. Journal of Plant Science Research, 39 (2) 141–152.
10. Barthwal S, Angel B, Angel A, Joshi V, Shareef BM, Peer NM, et al. 2023. Neutralizing possibilities of whole virion and mRNA vaccine triggered antibodies of Wuhan strain of SARS-CoV-2 with receptor binding domains of spike proteins of Delta and Omicron strains. Asian Pacific Journal of Tropical Medicine. 16(2): 92-94.
11. Khan AS, Angel A, Angel B, Joshi V, Shareef BM, Khaneja P, et al. 2022. Study of surface potential and hydrophobicity of amino acids in mutated spike proteins of variants of SARS-CoV-2 and its impact on attachment and internalization of virus with human host cells. Advance Studies in Biology. 14(1):111-127.
12. Angel A, Angel B, Joshi V, Jindal M, Rastogi P, Peer NM, et al. 2022. Correlation between hematological parameters, blood urea level and mortality of Covid-19 patients. International Journal of Health and Allied Sciences. 11:70-74
13. Angel B, Angel A, Joshi V, Jindal M, Rastogi P, Peer N, et al. 2021. Significance of addressal of clinical investigations of Kidney functions in recovery/mortality of COVID-19 patients: A preliminary study. Biosciences Biotechnology Research Communications. 14 (4): 1985-1991
14. Jethani J, Samad S, Kumar P, Angel B, Wig N, Choudhary A, Brijwal M, Kumar L, Dar L. Human metapneumovirus infection in haematopoietic stem cell transplant recipients: a case series. Virus disease. 2021 Mar;32(1):140-145. doi: 10.1007/s13337-021-00670-x.
15. Joshi AP, Angel A, Angel B, Baharia RK, Rathore S, Sharma N, Yadav K, Thanvi S, Thanvi I, Joshi V. 2018. In-silico designing and testing of primers for Sanger Genome Sequencing of Dengue virus Types of Asian Origin. Journal of Genomics, 6:34-40. doi: 10.7150/jgen.22460
16. Thanvi I, Angel A, Angel B, Joshi V, Bohra N, Chouhan R. 2017. Protein profiling of Nasopharyngeal cells of patients of Pandemic Influenza A (H1N1) 2009 virus treated with Oseltamivir Oxalate. International Journal of Basic & Applied Medical Sciences, 7(2): 11-20. ISSN no. 2277-2103
17. Angel A, Angel B, Yadav K, Sharma N, Joshi V, Thanvi I, Thanvi S. 2017. Age of initial cohort of Dengue patients could explain the origin of disease outbreak in a setting: A case control study of Rajasthan, India. Virus Diseases, 28 (2): 205-208.  ISSN no. 2347-3584
18. Angel A, Angel B, Joshi AP, Baharia PK, Rathore S, Joshi V. 2016. First study of complete genome of Dengue -3 virus from Rajasthan, India: genomic characterization, amino acid variations and phylogenetic analysis. Virology Reports, 6, 32-40.
19. Charan S, Pawar K, Gavhale S, Tikhe CV, Charan N, Angel B, Joshi V, Patole M, Shouche Y. 2016. Comparative analysis of midgut bacterial communities of three Stegomyia mosquito species from dengue-endemic and -non-endemic areas of Rajasthan, India. Medical & Veterinary Entomology; 30(3), 264-277.ISSN no. 1365-2915
20. Angel A, Angel B, Joshi V. 2016. Rare occurrence of natural transovarial transmission of dengue virus and elimination of infected foci as a possible intervention method. Acta Tropica, 155, 1-5.
21. Angel B, Angel A, Joshi V. 2015. Multiple dengue viruses harboured by individual mosquitoes. Acta Tropica, 150, 107-110.
22. Angel A, Angel B, Bohra N, Joshi V. 2014. Structural study of mosquito ovarian proteins participating in Transovarial transmission of dengue viruses. International Journal of Current Microbiology and Applied Sciences, 3 (4), 565-572.
23. Angel A, Angel B, Joshi V, Kucheria K.  2014. Sequential emergence of serological responses of human hosts in a progressive outbreak of Dengue and Dengue Hemorrhagic Fever in Rajasthan, India. Indian Journal of Applied Research,4 (5), 24-26.
24. Joshi V, Angel A, Angel B, Kucheria K. 2013. Egg laying sites of Aedes aegypti and their elimination as the crucial etiological intervention to prevent dengue transmission in Western Rajasthan, India.  International Journal of Scientific Research,2 (12), 468-469.
25. Joshi V, Angel B, Purohit A, Singhi M, Angel A, Bohra N. 2012. Studies on dengue outbreak in an arid town Jodhpur, Rajasthan. Journal of Communicable diseases, 44(2), 109-113.
26. Joshi V, Angel B, Chauhan R, Bohra N, Angel A, Singhi M, Mathur A, Solanki A. 2012. Immunity in Dengue Hemorrhagic Fever patients could be sensitized by Fresh blood transfusion. Indian Journal of Medical Case Reports, 1(1), 13-14.
27. Joshi V, Angel B, Purohit A, Singh H, Bohra N, Angel A, Chouhan R, Singhi M, Mathur A. 2012. Cases of pandemic influenza A (H1N1) 2009 in Western Rajasthan, India. Indian Journal of Medical Research, 135 (3), 437-438.
28. Joshi V, Chalga MS and Angel B. 2011. Development of a software module for forecasting malaria outbreak based on an equation derived from real-time parameters. International Journal of Computer Application, 35(4), 12-15.
29. Angel B and Joshi V. 2009. Distribution of Dengue virus types in Aedes aegypti in Dengue endemic districts of Rajasthan, India. Indian Journal of Medical Research, 129, 665-668.
30. Angel B and Joshi V. 2008. Distribution and seasonality of vertically transmitted dengue viruses in Aedes mosquitoes in arid and semi-arid areas of Rajasthan, India. Journal of Vector Borne Diseases,45, 56–59.
31. Sharma K, Angel B, Singh H, Purohit A and Joshi V. 2008.        Entomological studies for surveillance and prevention of dengue in arid and semi-arid districts of Rajasthan, India. Journal of Vector Borne Diseases, 45, 140–149.
32. Angel B, Sharma K and Joshi V. 2008. Association of ovarian proteins with transovarial transmission of dengue viruses by Aedes mosquitoes in Rajasthan, India. Indian Journal of Medical Research, 128, 181-184

Patents granted/published/applied

1. Jain P, Shahid M, Angel B, De A, Angel A, Joshi V. 2023. Organo-Copper Complex and a Larvicidal Composition comprising the same. (Patent no. 202311010155, published).
2. Angel B, Angel A, Joshi V, Mehta I, Bhardwaj V, Shareef BM, Joshi R, Khaneja P. 2023. A High Efficacy Larvicidal Formulation from Calotropis procera. (Patent number. 202311059367, Published on September 2023)
3. Joshi V, Angel A, Angel B, Joshi R, Shareef BM. 2024. Vaccine Targeting Conserved Region of Coronavirus (Provisional Indian Patent Application no 202411030338, filed on April 15, 2024).
4. Shareef BM, Joshi V, Khaneja P, Angel A, Angel B, Joshi R. 2024. An Adenosine analogue based compound against Severe Acute Respiratory Syndrome-Coronavirus-2 (Provisional Patent no.  202411032512, filed on April 24, 2024).

Certifications

• Molecular Diagnosis of H1N1 viruses from National Institute of Virology, Pune
• Training on Bioinformatics tools from DMRC, Jodhpur
• Animal Cell culture and virus isolation from National Institute of Virology, Pune
• Open WHO course (Online) on “Antimicrobial Stewardship: A competency-based approach” by W.H.O.
• Open WHO course (Online) on “Pandemic Influenza Vaccines: National Deployment and Vaccination Plans” by W.H.O.
• Faculty development programme on “Amity academic structure & system” by Amity University, Noida.
• Hands on training in Cell culture techniques and Cytotoxicity assays”.
• Basic Molecular Biology Techniques relevant to cancer research” at National Institute of Cancer Prevention and Research (formerly ICPO), Noida, U.P.

Area of Interest

• Respiratory viral diseases
• Hepatitis & Hepatocellular Carcinoma
• Breast Cancer
• Auto-immune diseases
• Swine Flu (pdmH1N1)
• Dengue